Horm Metab Res 2008; 40(12): 907-910
DOI: 10.1055/s-0028-1087169
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

The Fatty Acid Amide Hydrolase (FAAH) Pro129Thr Polymorphism is not Associated with Severe Obesity in Greek Subjects

D. Papazoglou 1 , I. Panagopoulos 2 , N. Papanas 1 , T. Gioka 3 , T. Papadopoulos 1 , P. Papathanasiou 1 , O. Kaitozis 1 , K. Papatheodorou 1 , E. Maltezos 1
  • 1Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
  • 2Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
  • 3Laboratory of Biochemistry, University Hospital of Alexandroupolis, Greece
Further Information

Publication History

received 07.02.2008

accepted 10.06.2008

Publication Date:
25 September 2008 (online)

Abstract

Fatty amid acid hydrolase (FAAH) has been implicated at both protein and gene level with obesity. An association between Pro129Thr variant of the FAAH gene and obesity has been described, but various studies have yielded conflicting results. Our aim was to determine whether this polymorphism is related to severe obesity and whether it confers a risk for variability of quantitative metabolic traits in a cohort of Greek obese subjects. Two groups of severely obese subjects (BMI > 40 kg/m2) were studied: a group of 158 metabolically healthy and a group of 145 obese subjects with metabolic syndrome, which were compared to a control group consisting of 121 lean individuals. We did not find any association between the Pro129Thr polymorphism with severe obesity in both subgroups of obese subjects, between these two subgroups (p= 0.11) or on basic anthropometric characteristics in the three groups. Statistically significant differences were found for glucose and HDL in metabolically healthy subjects and HDL in the control group. The borderline significant p-values were not significant after correction for multiple testing. We were unable to find robust evidence of an association of the Pro129Thr variant with severe obesity, and any related quantitative traits among the obese Greek subjects examined.

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Correspondence

D. Papazoglou

Patriarhou Grigoriou 97–99

68100 Alexandroupolis

Greece

Phone: +30/255/107 47 25

Fax: +30/255/107 47 23

Email: dpapazog@med.duth.gr

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