Use of ‘Click Chemistry’ for
the Synthesis of Tetrazole-Containing Analogues of the Neuroprotective
Agent Glycyl-l-prolyl-l-glutamic
Acid

Kuo-yuan Hung; Paul W. R. Harris; Margaret A. Brimble

doi:10.1055/s-0028-1088128

LETTER

Use of ‘Click Chemistry’ for the Synthesis of Tetrazole-Containing Analogues of the Neuroprotective Agent Glycyl-l-prolyl-l-glutamic Acid

Kuo-yuan Hung, Paul W. R. Harris, Margaret A. Brimble*
Department of Chemistry, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand
Fax: +64(9)3737422; e-Mail: m.brimble@auckland.ac.nz ;

Abstract

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Abstract

Tetrazole-containing analogues of glycyl-l-prolyl-l-glutamic acid (GPE) were prepared by coupling of Cbz-glycyl-l-proline with tetrazole-containing glutamic acids followed by hydrogenation of the resultant tripeptide. Synthesis of the tetrazole-containing glutamic acids involved 1,3-dipolar cycloaddition of sodium azide to nitrile derivatives of the corresponding glutamic acids.

Key words

GPE - 1,3-dipolar cycloaddition - tetrazole - TMSI - BoPCl

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Referenzen

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