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Horm Metab Res 1979; 11(1): 14-19
DOI: 10.1055/s-0028-1092673
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© Georg Thieme Verlag KG Stuttgart · New York

On the Effect of Insulin on Glucose-6-Phosphate Dehydrogenase and Fatty Acid Synthetase Activity in Mouse Liver

Tova  Kukulansky , G.  Yagil
  • Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
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Publication History

Publication Date:
17 December 2008 (online)

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Abstract

Regulation of glucose-6-phosphate dehydrogenase and fatty acid synthetase activity in mouse liver is examined in diabetic and normal mice. Up to a 4-fold increase of both enzymes can be observed in streptozotocin diabetic mice when transferred to a fatless, inducing diet. Administration of insulin does not increase enzyme activity at several doses and under a variety of conditions. This is a strong indication that insulin is not a necessary component of the induction system.

Key words

Insulin - Liver - Glucose-6-Phosphate Dehydrogenase - Fatty Acid Synthetase - High Fat Diet