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Horm Metab Res 1979; 11(2): 147-149
DOI: 10.1055/s-0028-1092697
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© Georg Thieme Verlag KG Stuttgart · New York

The Influence of Maternal Somatostatin Administration on Fetal Brain Cell Proliferation and its Relationship to Serum Growth Hormone and Brain Trophin Activity

Vicki R. Sara1 , R.  Rutherford2 , G. A. Smythe2
  • 1Department of Psychiatry Karolinska Institute St. Göran's Hospital, Stockholm, Sweden
  • 2Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, Australia
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Publikationsdatum:
17. Dezember 2008 (online)

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Abstract

The effect of maternal somatostatin administration from days 14 to 20 of gestation was examined. Fetal body growth was unchanged but brain cell DNA synthesis per gram of tissue decreased. Maternal serum levels of growth hormone and brain trophin were elevated following treatment conclusion. It was suggested that this was a rebound phenomenon and that short term blockade of pituitary growth hormone release during somatostatin treatment had impaired fetal brain cell DNA synthesis.

Key words

Growth Hormone - Brain Growth-Promoting Activity - Somatostatin - Fetal Growth