Download PDF
Horm Metab Res 1979; 11(3): 228-232
DOI: 10.1055/s-0028-1092714
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Uptake and Metabolism of Exogenous and Endogenous Thyroxine in the Brain of Young Rats

E.  Vigouroux1 , J.  Clos2 , J.  Legrand2
  • 1Laboratoire de Physiologie Comparée de l'Université Pierre et Marie Curie, Paris, France
  • 2Laboratoire de Physiologie Comparée de l'Université des Sciences et Techniques du Languedoc, Montpellier, France
Further Information

Publication History

Publication Date:
17 December 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

The uptake of labelled exogenous thyroxine by the brain was determined in 10- and 30-day-old rats. It was three times higher and thyroxine was more deiodinated on day 10 than on day 30. On the other hand, the endogenous hormonal iodine content was estimated in both the brain and the isolated cortical neurones in young rats of the same ages equilibrated with 125I. On day 10, brain and neurons contained five times more thyroid hormones than on day 30. These results are discussed in the context of the relations previously discovered between development of thyroid function and brain maturation.

Key words

Thyroxine Uptake and Metabolism - Developing Brain - Isolated Neurones - Rat