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Horm Metab Res 1979; 11(3): 233-237
DOI: 10.1055/s-0028-1092715
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© Georg Thieme Verlag KG Stuttgart · New York

Formation and Metabolism of 3',5'-Diiodothyronine and 3,5-Diiodothyronine by Cultured Monkey Hepatocarcinoma Cells

K.  Sorimachi , H. J. Cahnmann
  • Clinical Endocrinology Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Bethesda, Maryland, U.S.A.
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Publication Date:
17 December 2008 (online)

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Abstract

Cultured monkey hepatocarcinoma cells were incubated with |3',5'-125I]diiodo-L-thyronine and with [3,5-125I]diiodo-L-thyronine. In both instances monodeiodination as well as sulfoconjugation took place. [3.-125I]iodothyronine and [3',5'-125I] diiodothyronine were identified as metabolites of [3'-5',-125I]-L-thyroxine in the cells, but neither [3-125I]-iodothyronine nor [3,5-125I] diiodothyronine was detected after incubation of the cells with [3,5-125I]-L-thyroxine. No products of diphenyl ether splitting were observed in the medium after incubation of the cells with either [3,5-125I] diiodo-L-thyronine or [3,5-125l]-L-thyroxine.

Key words

Monkey Hepatocarcinoma Cells - Metabolism of Thyroxine - Metabolism of Thyroxine Analogs