Abstract
Parathyroid hormone (PTH) was given intravenously to anesthesized adult dogs. Blood
flows were measured with electromagnetic probes in different vascular areas concomitant
with analysis of glycerol, free fatty acid, calcium, glucose, sodium, potassium, albumin,
carbon-dioxid and creatinine.
PTH consistently caused an immediate increment in blood flow in the celiac vasculature
and a following, less pronounced increase in the renal artery. These changes were
effectuated by a vasodilatation. The degree and duration of the flow increments were
dose dependent. The celiac artery was more sensitive to the effect of PTH than the
renal artery. In celiac artery maximal increase above basal flow was 58 ± 27% (Mean
± S.D.), in renal artery 25 ± 12%.
A significant lipolytic action of PTH was consistently notable within minutes after
the administration of PTH. The other parameters analysed in blood remained unchanged
sixty to ninety minutes after the PTH injections. Then a hypercalcemic effect of PTH
appeared. A lipolytic action of PTH could be demonstrated with PTH doses which did
not induce hypercalcemia.
Key words
Parathyroid Hormone - Circulation - Lipolysis - Calcium
