Suppression of Luteinization in the Baboon by Thyrotrophin-Releasing Hormone (TRH)

N. Hagino; A. V. Schally

doi:10.1055/s-0028-1093515

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1977; 9(4): 290-293
DOI: 10.1055/s-0028-1093515

Originals

Suppression of Luteinization in the Baboon by Thyrotrophin-Releasing Hormone (TRH)

N. Hagino , A. V. Schally

Department of Anatomy, University of Texas Health Science Center at San Antonio, and Southwest Foundation for Research and Education, San Antonio, Texas, USA
Veterans Administration Hospital, Endocrine & Polypeptide Labs. and Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA

Abstract

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Abstract

Parenteral administration of 40 µg of synthetic thyrotrophin releasing hormone (TRH) which began two days prior to ovulation and continued for four days suppressed the luteinization of corpus luteum as judged by the lower level of plasma progestin. In contrast, injections of saline had no effect. Simultaneous injections of 300 µg of synthetic LHRH in TRH treated baboons brought about a resumption of postovulatory rise of plasma progestin. Injections of TRH in the early luteal phase did not suppress the postovulatory rise of progestin. It is, therefore, inferred that injections of TRH suppress the midcycle LH rise and subsequently suppress the luteinization of corpus luteum, rather than exerting a direct effect on the ovary of the baboon.

Key words

Baboon - TRH - LHRH - Plasma Progestin - Luteinization

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