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Horm Metab Res 1977; 9(1): 85-89
DOI: 10.1055/s-0028-1093590
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© Georg Thieme Verlag KG Stuttgart · New York

Effects of Acetoxyprogesterone upon Glycosaminoglycans in the Uterus and Salivary Glands of Rats[*]

J. A. Kofoed , A. B. Houssay , A. A. Tocci , H. M. Curbelo , C.  Barcelo
  • Department of Physiology, Schools of Medicine and Dentistry, University of Buenos Aires, Argentina
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

The isolation and characterization of glycosaminoglycans was performed in uterus and submaxillary glands of castrated female rats receiving daily doses of 20 or 200 µg of acetoxyprogesterone and 100 or 1000 µg of progesterone. Chromatographic separation of glycosaminoglycans was performed on cellulose microcolumns. The uronic acid concentration in the uterus was decreased by acetoxyprogesterone, in every chromatographic fraction, but not by progesterone. The uronic acid concentration in the submaxillary glands was decreased by acetoxyprogesterone in fractions 1 (glycoproteins) and 2 (hyaluronic acid) and by progesterone in fractions 1 (glycoproteins), 2 (hyaluronic acid) and 7 (heparin).

Key words

Acetoxyprogesterone - Progesterone - Glycosaminoglycans - Uterus - Submaxillary Glands - Chromatographic Separation

1 This work was partly supported by research grants from the University of Buenos Aires and from the Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina.

1 This work was partly supported by research grants from the University of Buenos Aires and from the Consejo Nacional de Investigaciones Cientificas y Técnicas, Argentina.

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