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Horm Metab Res 1976; 8(4): 279-281
DOI: 10.1055/s-0028-1093635
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© Georg Thieme Verlag KG Stuttgart · New York

Urinary Cyclic 3',5'-Adenosine Monophosphate (cAMP) in Diabetic Subjects with and without Symptomatic Hypoglycemia and in Normal Subjects with Insulin-Induced Hypoglycemia[*]

H. v. Lilienfeld-Toal , B.  Willms
  • Medizinische Universitäts-Klinik, Bonn, and Diabetes Klinik, Bad Lauterberg, Germany
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Publication Date:
23 December 2008 (online)

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Abstract

Urinary cAMP was investigated in diabetic subjects. It was found normal in patients on oral antidiabetics and on insulin in good or poor control. Patients with insulin-induced symptomatic hypoglycemia, however, excreted increased amounts of cAMP in the urine.

To demonstrate the significance of hypoglycemia we induced hypoglycemia by i.v.-injection of 0.15 U insulin/kg body weight in six normal subjects. An increase of urinary cAMP was found even during the first 15 minutes with maximal hypoglycemia.

Determination of urinary cAMP seems to be helpful in the diagnosis of unrecognized hypoglycemia and counterregulation.

Key words

Urinary Cyclic AMP - Diabetes mellitus - Hypoglycemia - Counterregulation

1 The results have in part been presented at the 9th Congress of the Deutsche Diabetes Gesellschaft in Travemünde 1974.

1 The results have in part been presented at the 9th Congress of the Deutsche Diabetes Gesellschaft in Travemünde 1974.

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