In the present study using an isolated perfused preparation of canine jejunum and
pancreas, an insulin-releasing factor was found in the venous effluent of the jejunum.
Insulin secretion by the pancreas rose twofold after 10% glucose was infused in the
lumen of the jejunum and remained at a high level even after the stimulus was discontinued.
No modification of the exocrine pancreatic secretion occurred during the insulin release,
and therefore it seems unlikely that gastrin, secretin or cholecystokinin-pancreozymin
were released by the jejunal mucosa. In control experiments the values of hyperglycaemia
observed previously and intraluminal hyperosmolarity were tested: at these levels,
they did not affect insulin secretion. The nature of this intestinal insulin-releasing
factor remains unknown however, but may be identifiable when intestinal hormones in
blood can be assayed reliably.
Intestinal Hormones - Insulin - Oral Glucose - Secretin - Pancreozymin - Intestinal
Insulin Releasing Factor
