Adipose tissue of fed and fasted weanling rats with or without hypothalamic obesity
has been studied in vitro with regard to glucose metabolism and the response to added
insulin. In rats with hypothalamic obesity fasting did not alter basal glucose utilization
or the responsiveness of adipose tissue to added insulin. Adipose tissue of fasted
control rats showed decreased basal glucose metabolism and less insulin responsiveness
compared to tissue from fed control rats and fed or fasted rats with hypothalamic
obesity. The results indicate that fasting does not produce insulin resistance in
adipose tissue of rats with hypothalamic obesity. The absence of adipose tissue insulin
resistance may contribute to the hypoglycemia produced by the fasting of rats with
hypothalamic obesity.
Adipose Tissue - Insulin Responsiveness - Hypothalamic Obesity - Weanling Rat
