© Georg Thieme Verlag KG Stuttgart · New York
Inhibition of Glucagon Secretion in the Human Newborn by Simultaneous Administration of Glucose and Insulin
07 January 2009 (online)
Glucose (1 gm/kg body weight) was administered intraportally to newborn infants, either alone or with intraportal insulin (0.1 or 0.3 U/kg body weight). As shown earlier, glucose alone did not suppress portal plasma glucagon; in contrast glucose plus insulin (at both doses used) resulted in a significant decrease in portal plasma glucagon. These data support the concept that insulin plays an important role in the physiologic sensitiveness of the alpha cell to glucose.
Insulin - Glucagon - Glucose - Human Newborn - Alpha Cell - Beta Cell - Glucose Homeostasis