Horm Metab Res 1974; 6(4): 267-271
DOI: 10.1055/s-0028-1093845
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Intracellular Transport and Storage of Newly Synthesised Proteins in the Guinea Pig Pancreatic A Cell

S. L. Howell , C.  Hellerström , M.  Tyhurst
  • School of Biological Sciences, University of Sussex, Falmer, Brighton, Sussex, U.K.
Further Information

Publication History

Publication Date:
08 January 2009 (online)

Abstract

The pathway and time course of the intracellular transport of new synthesised proteins in the guinea pig pancreatic A cell has been determined by electron microscopic radioautography. Protein biosynthesis occurs in the elements of the rough surfaced endoplasmic reticulum, the newly synthesised proteins being transferred via transitional areas to the Golgi complex where they may be present from 20-50 minutes after labelling. Storage granules containing newly synthesised proteins are found at 50 or 120 minutes after the end of pulse-labelling. The cellular mechanisms for the biosynthesis, intracellular transport and storage of proteins in the A cell apparently closely resemble those previously described in the B cells of rats and guinea pigs.

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