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DOI: 10.1055/s-0028-1093846
© Georg Thieme Verlag KG Stuttgart · New York
Sensitivity to Glucose of an Intestinal Factor Stimulating Insulin Release[*]
Publication History
Publication Date:
08 January 2009 (online)
Abstract
The existence of a hormonal mechanism regulating the release of insulin in response to a glucose load in the duodenal mucosa, is now well established. However, if several peptides are known to possess a β-cytotropic action, little is known of the effect of glucose on the stimulation of these hormones.
In order to study this system, the duodenal mucosae of a first series of rats were removed after a glucose load. Aqueous extracts of these mucosae were then injected into the coeliac trunk of a second series of rats. The injection of duodenal mucosa extracts of fasting rats significantly increased the insulin response of the receptor rat. However, the insulin release after injection of extracts from rats sacrificed 5 and 45 minutes after glucose induced a marked increases whereas extracts from rats sacrificed 15 and 30 minutes after glucose induced a lower response than that obtained with the extracts from fasting rats.
This finding suggests that the hormonal system of the duodenal mucosa is sensitive to glucose as an activator. Activation has been shown to occur in two phases.
Key words
Intestinal Hormone - Oral Glucose - Oral Amino Acids Load - Insulin - Secretin - Radioimmunoassay
1 *This work was supported in part by the "Fonds d'étude ROCHE." (Bale) Switzerland, and in part by a grant from Rentenanstalt Insurance Co. (Zürich) Switzerland.
1 *This work was supported in part by the "Fonds d'étude ROCHE." (Bale) Switzerland, and in part by a grant from Rentenanstalt Insurance Co. (Zürich) Switzerland.