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Horm Metab Res 1974; 6(2): 161-164
DOI: 10.1055/s-0028-1093864
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© Georg Thieme Verlag KG Stuttgart · New York

Peptides Obtained from Porcine Calcitonin After Degradation by a Human Plasma Fraction[*]

R. K. O'Dor [**] , F. E. Newsome , C. O. Parkes , D. H. Copp
  • Department of Physiology, Faculty of Medicine, The University of British Columbia, Vancouver, Canada
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

A preparation was obtained from human plasma Cohn fraction IV-1 by chromatography on CM-Sephadex and Sephadex G-200 which reduced the hypocalcemic activity of porcine calcitonin. Neither human nor salmon calcitonin is affected by the preparation. After prolonged incubation of the material with porcine calcitonin the calcitonin was cleaved into four peptide fragments at the arginine residues. The peptides have been isolated and their amino acid composition determined. Salmon calcitonin remained intact.

Key words

Porcine Calcitonin - Salmon Calcitonin - Human Calcitonin - Inactivation - Human Plasma

1 Supported by grants from the Medical Research Council of Canada and the British Columbia Medical Research Foundation.

1 Supported by grants from the Medical Research Council of Canada and the British Columbia Medical Research Foundation.

2 Medical Research Council of Canada Studentship holder. Present address: Biology Department, Dalhousie University Halifax, Nova Scotia

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