Monocomponent and commercial porcine insulin preparations administered with Freund's
adjuvant, induced insulin antibodies in rabbits. The results show that the proinsulin-like
contaminants in commercial insulin are not the essential stimuli for insulin antibody
formation, and that purification of insulin per se is not sufficient to render insulin
non-immunogenic. The physical state of insulin is more important in its immunogenicity.
Monocomponent Insulin - Insulin Antibodies
