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Horm Metab Res 1974; 6(3): 177-180
DOI: 10.1055/s-0028-1093867
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© Georg Thieme Verlag KG Stuttgart · New York

Influence of Altered States of Calcium Homeostasis on Insulin Secretion in Rats and Rabbits

J. T. Pento [*] , A.  Kagan , S. M. Glick
  • Medical Services, Coney Island Hospital, affiliated with Maimonides Medical Center, Brooklyn, New York, USA
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

The influence of experimental alterations in plasma calcium levels on glucose-stimulated insulin release in vivo was investigated. Insulin secretion after an intravenous pulse injection of glucose in hypocalcemic, parathyroidectomized rats was only 40% of the response observed in the sham-operated controls. In contrast, plasma insulin levels in response to glucose infusion were 25-275% higher in rabbits made hypercalcemic by calcium infusion than in control animals.

Key words

Insulin Secretion - Calcium - Glucose

1 Present address: Department of Pharmacology Colleges of Pharmacy and Medicine, University of Oklahoma, Norman, Oklahoma 73069, USA