An exercise load (450 Kpm/min for 20 min; 75 W) was performed 4 hours after the beginning
of the midday meal in 7 healthy men and in 6 insulin dependent diabetic men perfectly
controlled. A rise in plasma HGH levels was observed in 6 out of the 7 healthy men:
the mean maximal values were 6.3 ± 1.7 ng/ml 40 minutes after the beginning of the
exercise (0.8 ± 0.6 ng/ml before it). No HGH secretion was observed during the 80
minutes of blood sampling in the 6 normoglycemic insulin-treated diabetic men with
initial plasma HGH values of 1.0 ± 0.6 ng/ml. Mean plasma glucose values were identical
in both groups during exercise. Plasma insulin assays were performed in the healthy
subjects and in the 4 recently insulin treated diabetic subjects with no acquired
insulin antibodies. The mean plasma insulin values observed in diabetics were about
2 times higher than in nondiabetics despite identical mean plasma glucose levels.
It is suggested that this peripheral blood hyperinsulinism associated with normoglycemia
may have blocked HGH secretion in these diabetic subjects submitted to exercise in
the post prandial state.
Human Growth Hormone - Plasma Insulin - Blood Glucose - Insulin-Treated Diabetes -
Exercise
