Studies of the Action of Neutral Red on Glycemia and on Insulin and Glucagon Secretion in the Dog

Abstract

The intravenous administration of neutral red in the normal anesthetized dog produces hyperglycemia, an increase in the secretions of glucagon and insulin measured in the pancreatico-duodenal vein, a sharp drop in the arterial blood pressure and an increase in the secretion of catecholamines by the adrenal medulla. In adrenalectomized dogs there is no significant increase in the glycemia, the average secretions of insulin and of glucagon rise but in a less striking manner than in the normal dog. The hyperglycemia produced by neutral red, while due in part to the secretion of glucagon, is also the result of other factors, particularly the catecholamine secretion by the adrenal glands. It is important to take note of the strong hypotension produced by the intravenous administration of neutral red.

Key words

Neutral Red - Glycemia - Glucagon Secretion - Insulin Secretion - Blood Pressure - Catecholamines Release - Adrenalectomized Dogs