Horm Metab Res 1972; 4(4): 254-256
DOI: 10.1055/s-0028-1094061

© Georg Thieme Verlag KG Stuttgart · New York

Early Responses of Liver to Cortisone in Alloxan-Diabetic Rats

J.  Hanoune [*] , A. M. Chambaut [**]
  • Institut de Pathologie Moléculaire[***], Paris, France
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Publication History

Publication Date:
07 January 2009 (online)


When administered to alloxan-diabetic rats, cortisone elicits the same early hepatic responses which are observed in normal rats: increase of tyrosine transaminase and tryptophane oxygenase activities, increased incorporation of radioactive precursors into RNA, enhanced glycogen deposition. It is therefore likely that the Cortisol action upon liver is not dependent on the presence of insulin.

1 Chargé de Recherches à l'Institut National de la Santé et de la Recherche Médicale

2 Chargée de Recherches au Centre National de la Recherche Scientifique

3 Institute d'Université, Group U15 de I'lnstitut National de la Santé et de la Recherche Médicale, Laboratoire associé au Centre National de la Recherche Scientifique.