Early Responses of Liver to Cortisone in Alloxan-Diabetic Rats

J. Hanoune; A. M. Chambaut

doi:10.1055/s-0028-1094061

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Horm Metab Res 1972; 4(4): 254-256
DOI: 10.1055/s-0028-1094061

Originals

Early Responses of Liver to Cortisone in Alloxan-Diabetic Rats

J. Hanoune [*] , A. M. Chambaut [**]

Institut de Pathologie Moléculaire[***], Paris, France

Further Information

Publication History

Publication Date:
07 January 2009 (online)

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Abstract

When administered to alloxan-diabetic rats, cortisone elicits the same early hepatic responses which are observed in normal rats: increase of tyrosine transaminase and tryptophane oxygenase activities, increased incorporation of radioactive precursors into RNA, enhanced glycogen deposition. It is therefore likely that the Cortisol action upon liver is not dependent on the presence of insulin.

Key words

Insulin - Cortison - Liver - Alloxan-Diabetes - Glycogen.

1 Chargé de Recherches à l'Institut National de la Santé et de la Recherche Médicale

2 Chargée de Recherches au Centre National de la Recherche Scientifique

3 Institute d'Université, Group U15 de I'lnstitut National de la Santé et de la Recherche Médicale, Laboratoire associé au Centre National de la Recherche Scientifique.