Horm Metab Res 1972; 4(4): 271-273
DOI: 10.1055/s-0028-1094064
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© Georg Thieme Verlag KG Stuttgart · New York

Studies on the Regulation of a Sex-Associated Protein in Rat Liver[*]

II. Effect of Reserpine, Catapresan and Mesterolone on its BiosynthesisP.  Chandra , H.  Orii , H.  Feller , A.  Wacker
  • Institut für Therapeutische Biochemie der Universität Frankfurt/Main, Germany
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Publikationsdatum:
07. Januar 2009 (online)

Abstract

A sex-dependent protein from male rat liver was isolated. Male rats receiving reserpine for 15-20 weeks did not possess this protein in the liver. The growth of testes and seminal vesicles in experimental animals was also inhibited. Similar observations were made on male rats treated with catapresan, a hypotensive drug.

The reserpine inhibition of sex-dependent protein biosynthesis and testicular weights could be reversed by a simultaneous treatment with mesterolone, an androgen without any antigonadotropic activity.

1 Dedicated to Dr. Otto Ambros on his 70th birthday

1 Dedicated to Dr. Otto Ambros on his 70th birthday