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Horm Metab Res 1972; 4(1): 8-10
DOI: 10.1055/s-0028-1094107
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© Georg Thieme Verlag KG Stuttgart · New York

Increased Glomerular Clearance to (51CR) EDTA in Short-Term Insulin Treated Diabetics

J.  Ditzel , M.  Brinkløv , P.  Vestergaard
  • Department of Medicine II , Aalborg Regional Hospital, Aalborg, Denmark
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

The plasma disappearance curve of (51 Cr) EDTA after a single injection of 15 µc/10 kg was studied in 23 diabetic subjects with a duration of diabetes of less than 10 years and with no clinical evidence of microangiopathy as compared to 23 non-diabetic control subjects. The mean renal clearance value, calculated according to the mathematical model provided by Sapirstein, Vidt, Mandel and Hanusek (1955), was significantly increased (p < 0.02) in the diabetic groups as opposed to the non-diabetic group: GFR: 131.4 (S.D.21.05) and 116.2 (S.D.19.21) ml/min/1.73 m2 respectively. No statistically significant correlation could be demonstrated between the clearance values and the duration of diabetes, the age of the subject, insulin dosage, and the fasting blood-sugar.

Key words

51Cr-EDTA Clearance - Inulin Clearance - Functional Microangiopathy - Diabetic Microangiopathy - Glomerular Filtration - Capillary Permeability

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