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Horm Metab Res 1971; 3(4): 262-266
DOI: 10.1055/s-0028-1094145
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© Georg Thieme Verlag KG Stuttgart · New York

The Effect of Drugs on Lipogenesis from Glucose and Palmitate in Human Adipose Tissue

J.P. D. Wilson , D. J. Galton
  • Endocrine Unit, Department of Medicine, Royal Postgraduate Medical School, London W. 12, England
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Publication Date:
07 January 2009 (online)

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Abstract

Several drugs were tested for their ability to inhibit lipogenesis in human adipose tissue. Only fenfluramine was found to inhibit the incorporation of T-palmitate and 14C-glucose into neutral lipid in intact tissue. This effect was observed at drug concentrations above 1 mM.

Fenfluramine inhibited lipogenesis in broken-cell preparations of human adipose tissue at concentrations of 1 mM and above. However, in this system the N-benzoyloxyethyl derivative of fenfluramine, S. 1513, was also found to inhibit lipogenesis. This drug was more potent than fenfluramine, a significant inhibition being observed at 0.4 mM

During inhibition of lipogenesis in homogenates of adipose tissue by fenfluramine radioactitivity was found to accumulate in long-chain acyl-CoA which suggests that the drug may interfere with acylation of glycerol 3-phosphate.

Evidence that fenfluramine may have a similar effect in vivo was considered, but the results were not statistically significant.

Key words

Lipogenesis - Adipose Tissue-Homogenate Fenfluramine

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