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Horm Metab Res 1971; 3(4): 279-284
DOI: 10.1055/s-0028-1094149
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© Georg Thieme Verlag KG Stuttgart · New York

The Stimulation of Mitotic Activity in the Thymus and Bone Marrow of Rats by Kallikrein[*]

R. H. Rixon , J. F. Whitfield , J.  Bayliss
  • Division of Biology, National Research Council of Canada, Ottawa, Kia Org, Canada
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Publication History

Publication Date:
07 January 2009 (online)

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Abstract

A single intraperitoneal injection of a commercial preparation of kallikrein (3 or 5 units/100 gm) stimulated the mitotic activity of cells in the thymus gland and the bone marrow of rats. This effect was observed three to six hours after injection as an increase in the mitotic index and the accumulation of cells in the metaphase stage of mitosis by the mitotic blocking agent, colcemid. Kallikrein did not affect the mitotic activity of isolated thymic lymphocytes. The release of mitogenically-active kinins is proposed as the means by which kallikrein enhances cell proliferation in vivo.

Key words

Kallikrein - Mitotic Stimulation - Thymus - Bone Marrow

1 Issued as NRCC No. 12029

1 Issued as NRCC No. 12029

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