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Pharmacopsychiatry 1968; 1(4): 270-275
DOI: 10.1055/s-0028-1094225
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© Georg Thieme Verlag KG Stuttgart · New York

A Substitution Technique for Determining Barbiturate-like Physiological Dependence Capacity in the Dog1

Gerald A. Deneau2 , Salamuddin Weiss3 , 4
  • 2Present address: Southern Research Institute, Birmingham, Alabama.
  • 3 Present address: Faculty of Medicine, University of Kabul, Kabul, Afghanistan.
1 This investigation was supported in part by a grant awarded by the Committee an Problems of Drug Dependence, National Academy of Sciences-National Research Council, from funds contributed by a group of interested pharmaceutical manufacturers and, in part, by USPHS Grant MH-05320.
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Publication History

Publication Date:
20 January 2009 (online)

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Summary

1. The time course of maximal development of physiological dependence to sodium barbital in dogs is presented.

2. A method for grading the severity of the abstinence Syndrome from barbiturates is presented.

3. A rapid method for determining the potential barbiturate like physiological dependence capacity of sedative-hypnotic agents is presented. Shortcomings of this procedure are also discussed.

4 Supported by a grant from the International Institute of Education.

Zusammenfassung

1. Der zeitliche Verlauf der Entwicklung maximaler Abhängigkeit von Natriumbarbital bei Hunden wird beschrieben.

2. Eine Methode der Beurteilung des Schweregrades von Abstinenzerscheinungen wird dargelegt.

3. Ein Verfahren zur raschen Bestimmung der Potenz sedativ-hypnotisch wirksamer Pharmaka zur Erzeugung einer barbituratähnlichen physiologischen Abhängigkeit wird angegeben. Nachteile der Methode werden erörtert.

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