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Horm Metab Res 1971; 3(1): 28-33
DOI: 10.1055/s-0028-1095043
DOI: 10.1055/s-0028-1095043
Originals
© Georg Thieme Verlag KG Stuttgart · New York
Stimulation by Growth Hormone of Deoxyribonucleic Acid Synthesis and Proliferation of Rat Thymic Lymphocytes[*]
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Publication History
Publication Date:
07 January 2009 (online)
Abstract
Growth hormone (GH) considerably increases the flow of cells into mitosis in rat thymic lymphocyte (thymocyte) populations maintained in vitro. This calcium-dependent, cyclic-AMP-mediated mitogenic action of GH is due to the rapid (within 60 minutes) stimulation of the initiation of deoxyribonucleic acid (DNA) synthesis in a part of the thymocyte population which is poised, or blocked, at the threshold of the DNA-synthetic (S) phase of the cell cycle. A possible mechanism by which GH, through the agency of cyclic AMP, could promote the initiation of DNA synthesis is discussed.
Key words
Growth Hormone - DNA Synthesis - Mitotic Stimulation - Thymocytes