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Horm Metab Res 1970; 2(4): 221-224
DOI: 10.1055/s-0028-1095087
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© Georg Thieme Verlag KG Stuttgart · New York

Circadian Rhythmicity of Hypothalamic CRH and its Central Nervous Regulation

K.  Retiene , F.  Schulz
  • Department of Endocrinology, Center of Internal Medicine, University of Frankfurt/Main, Germany
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

In contrast to the marked circadian rhythm of endocrine pituitary function only a slight fluctuation of hypothalamic CRH was observed in rats throughout the day. However, a standardized ether stress significantly reduced hypothalamic CRH in the morning and no alteration was observed in the evening, whereas pituitary ACTH increased for the same amount at each time of the day. The hypothesis is proposed that a special "rhythm center" in the CNS acts in an inhibitory way on hypothalamic hormone synthesis.

Key words

CRF - Pituitary ACTH - Ether Stress - Rhythm Center