Abstract
Male Sprague-Dawley rats received an intraperitoneal injection of 500 mg nicotinamide/kg
body weight. One, two, five and eight hours later, the livers were frozen rapidly
in liquid N2. The following metabolites were analyzed: lactate, pyruvate, glycerol-I-phosphate,
dihydroxyacetone-phosphate, malate, oxaloacetate, adenine nucleotides, glucose, glucose-6-phosphate,
fructose-1,6-diphosphate, phospho-enolpyruvate, acetyl-Coenzyme A, nicotinamide-adenine
dinucleotide, nicotinamide-adenine dinucleotide phosphate. In addition, the levels
of glycogen and triglycerides were determined.
Key words
Nicotinamide - Inhibition of Lipolysis - Redoxstate of the Cytosolic NAD-System -
Gluconeogenesis
1 Parts of this report were first presented at Verhandl. Dt. Ges. inn. Med., Wiesbaden
(22-25 April 1968).
2 Present address: Biochem. Institut der Univ. Freiburg, FRG.
3 Present address: Med. Kliniken und Polikliniken der Univ. Gießen, FRG.
