Senologie - Zeitschrift für Mammadiagnostik und -therapie 2008; 5(4): 257-263
DOI: 10.1055/s-0028-1098731
Wissenschaftliche Arbeit

© Georg Thieme Verlag Stuttgart ˙ New York

Bedeutung von Biomarkern in der Klassifizierung und Therapie des Mammakarzinoms

The Impact of Biomarkers in Breast Cancer Classification and TherapyC. Liedtke1 , L. Kiesel1
  • 1Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Münster
Further Information

Publication History

Publication Date:
29 December 2008 (online)

Zusammenfassung

Es gilt als gesichert, dass sich die Entität des Mammakarzinoms aus einer sehr heterogenen Gruppe von unterschiedlichen Tumorsubtypen zusammenzusetzen scheint, die sich hinsichtlich ihrer Prognose sowie ihrer therapeutischen Zugänglichkeit maßgeblich voneinander unterscheiden. Um diese Subtypen zu charakterisieren und differenzieren, bedarf es des Einsatzes einer Vielzahl von klinischen, pathologischen und molekularen Biomarkern. Diese Biomarker können sowohl singuläre Marker als auch ein mathematisches Modell auf der Basis verschiedener Marker darstellen. Ziel des Einsatzes von Biomarkern im klinischen Alltag wie im wissenschaftlichen Kontext ist es, Patientinnen mit Mammakarzinom anhand ihrer Erkrankung zu klassifizieren, eine Aussage über das individuelle Rezidivrisiko der Erkrankung zu treffen und letztlich die Patientin einer Erfolg versprechenden, maßgeschneiderten Therapie zuzuführen.

Abstract

Breast cancer is increasingly recognized as a heterogeneous mixture of distinct breast cancer subtypes which differ substantially with regard to prognosis and therapeutic approachability. Clinical, pathological and molecular biomarkers are needed to characterize and distinguish these subtypes. Biomarkers can be individual parameters as well as complex mathematical models consisting in several individual markers. They are employed to classify patients with breast cancer, define their individual prognosis and, most importantly, allow for the design of individual well-tailored therapeutic concepts.

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Dr. med. C. Liedtke

Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe · Universitätsklinikum Münster

Albert-Schweitzer Straße 33

48149 Münster

Phone: 02 51 / 8 34 80 02

Email: liedtkec@ukmuenster.de

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