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Int J Sports Med 2009; 30(6): 403-407
DOI: 10.1055/s-0028-1105937
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Influence of Puberty on Ghrelin and BMD in Athletes

J. Jürimäe 1 , E. Lätt 1 , K. Haljaste 1 , P. Purge 1 , A. Cicchella 2 , T. Jürimäe 1
  • 1Institute of Sport Pedagogy and Coaching Science, University of Tartu, Tartu, Estonia
  • 2Faculty of Exercise and Sport Sciences, University of Bologna, Bologna, Italy
Further Information

Publication History

accepted after revision November 11, 2008

Publication Date:
06 February 2009 (online)

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Abstract

The aim of our study was to examine the influence of elevated energy expenditure on ghrelin and BMD in young male competitive swimmers advancing from prepubertal to pubertal maturation levels. The study included 19 healthy swimmers (pubertal stage 1) aged between 10 and 12 years. The participants were at the pubertal stages 2 and 3, and 3 and 4 at the second and third year, respectively. Ghrelin was decreased only after the first year. No changes were observed in leptin during the study period. Testosterone increased according to the pubertal development at each measurements. IGF-I was increased at the third measurement compared to the first two measurements. Total and lumbar spine BMDs increased according to the pubertal development in all boys at each measurements, while no changes in femoral neck BMD were observed. Ghrelin was not related to BMD after adjusting for pubertal status. We conclude that ghrelin was decreased at onset of puberty, while no further changes in ghrelin were seen with advancing pubertal stage. Total and lumbar spine BMD increased, while no changes in femoral neck BMD occurred. Ghrelin did not appear to have a direct influence on BMD in young male competitive swimmers.

Key words

ghrelin - BMD - sexual maturation - competitive swimmers - boys

References

  • 1 Bellone S, Rapa A, Vivenza D, Castellino N, Petri A, Bellone J, Me E, Broglio F, Prodam F, Ghigo E, Bona G. Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood.  J Endocrinol Invest. 2002;  5 RC13-RC15
    PubMedGoogle Scholar
  • 2 Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat T, Van Der Lely AJ, Ghigo E. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.  J Clin Endocrinol Metab. 2004;  89 3062-3065
    CrossrefPubMedGoogle Scholar
  • 3 Clayton PE, Gill MS, Hall CM, Tillmann V, Whatmore AJ, Price DA. Serum leptin through childhood and adolescence.  Clin Endocrinol. 1997;  46 727-733
    CrossrefPubMedGoogle Scholar
  • 4 Duke PM, Litt IF, Gross RT. AdolescentsŽ self-assessment of sexual maturation.  Pediatrics. 1980;  66 918-920
    PubMedGoogle Scholar
  • 5 Duncan CS, Blimkie CJ, Cowell CT, Burke ST, Briody JN, Howman-Giles R. Bone mineral density in adolescent female athletes: relationship to exercise type and muscle strength.  Med Sci Sports Exerc. 2002;  34 286-294
    CrossrefPubMedGoogle Scholar
  • 6 Foster-Schubert KE, Tiernan A, Frayo RS, Schwartz RS, Rajan KB, Yasui Y, Tworoger SS, Cummings DE. Human plasma ghrelin levels increase during one-year exercise program.  J Clin Endocrinol Metab. 2004;  90 820-825
    CrossrefPubMedGoogle Scholar
  • 7 Garnett SP, Högler W, Blades B, Baur LA, Peat J, Lee J, Cowell CT. Relation between hormones and body composition, including bone, in prepubertal children.  Am J Clin Nutr. 2004;  80 966-972
    PubMedGoogle Scholar
  • 8 Gordon CL, Halton JM, Atkinson SA, Atkinson SA, Webber CE. The contributions of growth and puberty to peak bone mass.  Growth Dev Aging. 1991;  55 257-262
    PubMedGoogle Scholar
  • 9 Grimston SK, Morrison K, Harder JA, Hanley DA. Bone mineral density during puberty in western Canadian children.  Bone Miner. 1992;  19 85-96
    CrossrefPubMedGoogle Scholar
  • 10 Haqq AM, Farooqi IS, O’Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ. Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi Syndrome.  J Clin Endocrinol Metab. 2003;  88 174-178
    CrossrefPubMedGoogle Scholar
  • 11 Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kangawa K, Sugihara S. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents.  Diabetes. 2002;  51 3408-3411
    CrossrefPubMedGoogle Scholar
  • 12 Jürimäe J, Cicchella A, Jürimäe T, Lätt E, Haljaste K, Purge P, Hamra J, von Duvillard SP. Regular physical activity influences plasma ghrelin concentration in adolescent girls.  Med Sci Sports Exerc. 2007;  39 1736-1741
    PubMedGoogle Scholar
  • 13 Jürimäe J, Cicchella A, Tillmann V, Lätt E, Haljaste K, Purge P, Pomerants T, Jürimäe T. Effect of pubertal development on plasma ghrelin concentration in boys.  J Endocrinol Invest. 2008;  , [in Press]
    PubMedGoogle Scholar
  • 14 Jürimäe J, Haljaste K, Cicchella A, Lätt E, Purge P, Leppik A, Jürimäe T. Analysis of swimming performance from physical, physiological and biomechanical parameters in young swimmers.  Ped Exerc Sci. 2007;  19 70-81
    PubMedGoogle Scholar
  • 15 Jürimäe J, Jürimäe T. Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women.  Osteoporos Int. 2007;  18 1253-1259
    CrossrefPubMedGoogle Scholar
  • 16 Kanbur NÖ, Derman O, Kinik E. The relationships between pubertal development, IGF-1 axis, and bone formation in healthy adolescents.  J Bone Miner Metab. 2005;  23 76-83
    CrossrefPubMedGoogle Scholar
  • 17 Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach.  Nature. 1999;  402 656-660
    CrossrefPubMedGoogle Scholar
  • 18 Maccarinelli G, Sibilia V, Torsello A, Raimondo F, Pitto M, Giustina A, Netti C, Cocchi D. Ghrelin regulates proliferation and differentation of osteoblastic cells.  J Endocrinol. 2005;  184 249-256
    CrossrefPubMedGoogle Scholar
  • 19 Marzullo P, Verti B, Savia G, Walker GE, Guzzaloni G, Tagliaferri M, Di Blasio A, Liuzzi A. The relationship between active ghrelin and human obesity involves alterations in resting energy expenditure.  J Clin Endocrinol Metab. 2004;  89 936-939
    CrossrefPubMedGoogle Scholar
  • 20 Misra M. Bone density in the adolescent athlete.  Rev Endocr Metab Disord. 2008;  9 139-144
    CrossrefPubMedGoogle Scholar
  • 21 Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M, Ghio E. Neuroendocrine and peripherial activities of ghrelin: implications in metabolism and obesity.  Eur J Endocrinol. 2002;  440 235-254
    CrossrefPubMedGoogle Scholar
  • 22 Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding.  Nature. 2001;  409 194-198
    CrossrefPubMedGoogle Scholar
  • 23 Patel MB, Arden NK, Masterson LM, Phillips DI, Swaminathan R, Syddall HE, Byrne CD, Wood PJ, Cooper C, Holt RI. Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD).  Bone. 2005;  37 833-841
    CrossrefPubMedGoogle Scholar
  • 24 Pomerants T, Tillmann V, Jürimäe J, Jürimäe T. Relationship between ghrelin and anthropometrical, body composition parameters and testosterone levels in boys at different stages of puberty.  J Endocrinol Invest. 2006;  29 962-967
    PubMedGoogle Scholar
  • 25 Pomerants T, Tillmann V, Karelson K, Jürimäe J, Jürimäe T. Ghrelin response to acute aerobic exercise in boys at different stages of puberty.  Horm Metab Res. 2006;  38 752-757
    Article in Thieme ConnectPubMedGoogle Scholar
  • 26 Pomerants T, Tillmann V, Jürimäe J, Jürimäe T. The influence of serum ghrelin, IGF axis and testosterone on bone mineral density in boys at different stages of sexual maturity.  J Bone Miner Metab. 2007;  25 193-197
    CrossrefPubMedGoogle Scholar
  • 27 Roemmich JN, Clark PA, Mantzoros CS, Gurgol CM, Weltman A, Rogol AD. Relationship of leptin to bone mineralization in children and adolescents.  J Clin Endocrinol Metab. 2003;  88 599-604
    CrossrefPubMedGoogle Scholar
  • 28 Saggese G, Baroncelli GI, Bertelloni S. Puberty and bone development.  Best Pract Res Clin Endocrinol Metab. 2002;  16 53-64
    CrossrefPubMedGoogle Scholar
  • 29 Saito MT. Sexual maturation: self-evaluation of the adolescent.  Pediatrica. 1984;  6 111-115
    PubMedGoogle Scholar
  • 30 Tanner J. Growth at Adolescence. 2nd ed. Oxford, United Kingdom: Blackwell Scientific Publications 1962
  • 31 Veldhuis JD, Roemmich JN, Richmond EJ, Rogol AD, Lovejoy JC, Sheffield-Moore M, Mauras N, Bowers CY. Endocrine control of body composition in infancy, childhood, and puberty.  Endocr Rev. 2005;  26 114-146
    CrossrefPubMedGoogle Scholar
  • 32 Ward KA, Roberts SA, Adams JE, Mughal MZ. Bone geometry and density in skeleton of pre-pubertal gymnasts and school children.  Bone. 2005;  36 1012-1018
    CrossrefPubMedGoogle Scholar
  • 33 Whatmore AJ, Hall CM, Jones J, Westwood M, Clayton PE. Ghrelin concentrations in healthy children and adolescents.  Clin Endocrinol. 2003;  59 649-654
    CrossrefPubMedGoogle Scholar
  • 34 Yilmaz D, Ersoy B, Bilgin E, Gümüser G, Onur E, Pinar ED. Bone mineral density in girls and boys at different pubertal stages: relation with gonadal steroids, bone formation markers, and growth parameters.  J Bone Miner Metab. 2005;  23 476-482
    CrossrefPubMedGoogle Scholar

Correspondence

Dr. J. Jürimäe

Institute of Sport Pedagogy and Coaching Science

University of Tartu 18. Ülikooli St.

50090 Tartu

Estonia

Phone: +372/7/37 53 72

Fax: +372/7/37 53 73

Email: jaakj@ut.ee

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