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DOI: 10.1055/s-0028-1109088
© Georg Thieme Verlag KG Stuttgart · New York
Neue Entwicklungen in der Biopsiediagnostik früher und unklarer Lebertumoren
Recent developments in Biopsy Diagnosis of Early and Undefined Liver TumorsPublication History
Manuskript eingetroffen: 14.10.2008
Manuskript akzeptiert: 11.12.2008
Publication Date:
20 January 2009 (online)
Zusammenfassung
Die bioptische Diagnostik früher und hochdifferenzierter Lebertumoren stellt besondere Anforderungen, denen die moderne Pathologie in vielfältiger Weise gerecht wird. So wurden differenzierte morphologische Algorithmen und neue immunhistologische Marker zur Differenzialdiagnose des hochdifferenzierten HCC und eine neue prognostisch relevante, molekularpathologische und histologische Klassifikation des Leberzelladenoms entwickelt. Durch diese neuen diagnostischen Werkzeuge gelingt es heute unter Einbeziehung der „Matrixdiagnostik” bei fast allen dieser schwierigen Fälle eine zuverlässige diagnostische Einstufung zu erreichen.
Abstract
Biopsy diagnosis of early and highly differentiated liver tumors is difficult and complex. Modern pathology has met this challenge by several different means; elaborate morphological algorithms and novel immunohistological markers support the differential diagnosis of highly differentiated HCC and a new, predictive molecular pathological and histological classification of liver cell adenoma was developed. By these new diagnostic tools together with the so-called ‘matrix diagnosis’ a reliable diagnostic classification is now feasible in the vast majority of these difficult cases.
Schlüsselwörter
Leberbiopsie - Diagnose - Klassikation - Marker - Lebertumoren
Key words
liver biopsy - diagnosis - classification - marker - liver tumor
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Prof. Dr. Peter Schirmacher
Pathologisches Institut, Universität Heidelberg
Im Neuenheimer Feld 220 / 221
69120 Heidelberg
Phone: ++ 49 / 6221 / 562601
Fax: ++ 49 / 6221 / 565251
Email: peter.schirmacher@med.uni-heidelberg.de