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Fortschr Neurol Psychiatr 2009; 77(10): 585-590
DOI: 10.1055/s-0028-1109758
Kasuistik

© Georg Thieme Verlag KG Stuttgart · New York

Yohimbin, ein Alpha-2-Antagonist: Literaturübersicht zu psychiatrisch relevanten Wirkungen und Nebenwirkungen mit aktuellem Fallbericht

Psychiatric Effects and Side Effects of the Alpha-2-Antagonist Yohimbine: A Review of Literature and Case ReportM. Scherr1 , D. Schwerthoeffer1 , T. Froboese1 , F. Castrop2 , J. Bäuml1
  • 1Klinik und Poliklinik für Psychiatrie und Psychotherapie (Direktor: Univ.-Prof. Dr. H. Förstl), Klinikum rechts der Isar, Technische Universität München
  • 2Neurologische Klinik und Poliklinik (Direktor: Univ.-Prof. Dr. B. Hemmer), Klinikum rechts der Isar, Technische Universität München
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Publication History

Publication Date:
09 October 2009 (online)

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Zusammenfassung

Wir beschreiben den Fall einer 21-jährigen Patientin, die 2-malig den Alpha-2-Antagonisten Yohimbin zur Gewichtsreduktion einnahm. In engem zeitlichem Zusammenhang mit dem Beginn der Einnahme standen Verhaltensauffälligkeiten, Änderungen in Konsumverhalten und Suchterleben (Alkohol, Kokain) und Suizidalität. Daten aus präklinischen und klinischen Studien werden diskutiert, die einen möglichen kausalen Zusammenhang untermauern. Vorangestellt ist eine Literaturübersicht über psychische Wirkungen und Nebenwirkungen von Yohimbin.

Abstract

We describe a 21-year old female patient who had taken the alpha-2-antagonist yohimbine for weight-loss. The patient reported alterations in alcohol- and cocaine-seeking along with changes in defensive behaviour, including suicidal tendencies. Pre-clinical and clinical studies are discussed, which support the hypothesis of a causal relationship. We added an overview of relevant psychiatric effects and side effects of yohimbine.

Schlüsselwörter

Yohimbin - Kokain - Alkohol - Verhalten - Suizidalität

Key words

Yohimbine - cocaine - alcohol - behaviorial alterations - suicidality

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Martin Scherr

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München

Ismaningerstraße 22

81675 München

Email: martin_scherr@hotmail.com