Horm Metab Res 2009; 41(2): 159-163
DOI: 10.1055/s-0028-1119408

© Georg Thieme Verlag KG Stuttgart · New York

Wnt-signalling and the Metabolic Syndrome

S. Schinner 1
  • 1Department of Endocrinology, Diabetes and Rheumatology, University Hospital Düsseldorf, Düsseldorf, Germany
Further Information

Publication History

received 24.09.2008

accepted 09.12.2008

Publication Date:
12 February 2009 (online)


The Wnt-signalling pathway plays a well-established role in embryogenesis and tumourigenesis. However, recent data puts Wnt-signalling in the context of metabolic disease. In vitro and in vivo data characterised the role of Wnt-signalling molecules in the regulation of adipocyte differentiation (adipogenesis). Furthermore, Wnts play a pivotal role in regulating pancreatic beta-cell function and mass. In addition, studies found polymorphisms within the gene encoding TCF7L2, a Wnt-regulated transcription factor, to contribute an increased risk to develop type 2 diabetes mellitus in humans. This review will summarise recent aspects of Wnt-signalling in these pathophysiologic events and discuss the contributions of dysregulation in Wnt-signalling to features of the metabolic syndrome.



S. Schinner, MD 

Department of Endocrinology, Diabetes and Rheumatology

University Hospital Düsseldorf

Moorenstr. 5

40225 Düsseldorf

Phone: +49/211/811 78 10

Fax: +49/211/811 78 60

Email: [email protected]