Horm Metab Res 2009; 41(7): 554-558
DOI: 10.1055/s-0029-1192034
Humans, Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Cholesteryl Ester Transfer Protein I405V Polymorphism Influences Apolipoprotein A-I Response to a Change in Dietary Fatty Acid Composition

M. Darabi 1 , A. A. Abolfathi 1 , M. Noori 1 , A. Kazemi 2 , A. Ostadrahimi 2 , A. Rahimipour 1 , M. Darabi 3 , K. Ghatrehsamani 1
  • 1Department of Biochemistry, School of Medicine, Tabriz University (Medical Sciences), Tabriz, Iran
  • 2Nutritional Research Center, Tabriz University (Medical Sciences), Tabriz, Iran
  • 3Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
Further Information

Publication History

received 25.10.2008

accepted 07.01.2009

Publication Date:
25 February 2009 (online)


The aim of the present study was to investigate whether the cholesteryl ester transfer protein (CETP) I405V polymorphism modifies the response to changes in the dietary ratio of polyunsaturated to saturated fat (P:S). The population included 85 healthy subjects with the different I405V genotypes (35 II, 36 IV, and 14 VV) assigned to two consecutive 28-day experimental period. All subjects consumed a high-P:S with P:S of 1.2 for the first period and a low-P:S with a P:S of 0.3 for the next 28-day period. At the first and end of each dietary period, serum lipid, lipoprotein, and CETP concentrations were measured. At screening, lipid or lipoprotein concentrations were not significantly different among CETP I405V genotype groups. After the low-P:S diet, subjects carrying V allele had greater reduction in apoA-I and HDL cholesterol (HDL-C) than subjects with II genotype. A genotype-by-diet interaction effect was observed on apoA-I (p=0.016) concentrations. In conclusion, the CETP I405V polymorphism contributes to the unfavorable changes of apoA-I and HDL-C when a high-P:S diet was replaced with a low-P:S diet.



M. Darabi

Department of Biochemistry

School of Medicine

Tabriz University (Medical Sciences)

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