Association of GNB3 C825T Polymorphism with Peak Oxygen Consumption

Abstract

The C825T single nucleotide polymorphism (SNP) in the guanine nucleotide-binding protein, beta polypeptide 3 (GNB3) gene gives rise to a splice variant, GNB3s that has enhanced G protein activation and signal transduction activity. This variant has been reported to be associated with cardiovascular disease, diabetes and obesity. We studied this SNP in 95 healthy 18 to 30 year-old African American university students to determine its association with aerobic capacity and cardiorespiratory fitness as measured by peak oxygen consumption (VO₂peak). We also tested the effect of heart rate variability (HRV) as an independent predictor of VO₂peak. We tested the association of the SNP and HRV with VO₂peak in a multivariate regression analysis with appropriate adjustments of covariates, under dominant and recessive models. We found a significant independent association of the 825T allele with VO₂peak under the dominant model (β-coef.=−0.101, P=0.0442). We also observed that HRV marginally influenced VO₂peak. This finding suggests that GNB3 C825T polymorphism is associated with VO₂peak which is influenced by autonomic modulation of heart rate in African Americans.

GNB3 - cardiorespiratory fitness - heart rate variability - African-Americans - autonomic modulation

References

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