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Int J Sports Med 2009; 30(5): 315-319
DOI: 10.1055/s-0029-1202259
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Association of GNB3 C825T Polymorphism with Peak Oxygen Consumption

M. U. Faruque 1 , R. M. Millis 2 , G. M. Dunston 3 , J. Kwagyan 4 , V. Bond 5  Jr. , C. N. Rotimi 6 , T. Davis 7 , R. Christie 5 , A. L. Campbell 8
  • 1National Human Genome Center, Howard University, Washington, D.C., United States
  • 2Department of Physiology & Biophysics, Howard University, Washington, D.C., United States
  • 3Department of Microbiology, Howard University, Washington, D.C., United States
  • 4Department of Community and Family Medicine, Howard University, Washington, D.C., United States
  • 5Department of Health, Human Performance & Leisure Studies, Howard University, Washington, D.C., United States
  • 6National Human Genome Research Institute, NIH, Bethesda, MD, United States
  • 7Department of Genetics and Human Genetics Howard University, Washington, D.C., United States
  • 8Department of Psychology, Howard University, Washington, D.C., United States
Further Information

Publication History

accepted after revision July 6, 2008

Publication Date:
19 March 2009 (online)

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Abstract

The C825T single nucleotide polymorphism (SNP) in the guanine nucleotide-binding protein, beta polypeptide 3 (GNB3) gene gives rise to a splice variant, GNB3s that has enhanced G protein activation and signal transduction activity. This variant has been reported to be associated with cardiovascular disease, diabetes and obesity. We studied this SNP in 95 healthy 18 to 30 year-old African American university students to determine its association with aerobic capacity and cardiorespiratory fitness as measured by peak oxygen consumption (VO2peak). We also tested the effect of heart rate variability (HRV) as an independent predictor of VO2peak. We tested the association of the SNP and HRV with VO2peak in a multivariate regression analysis with appropriate adjustments of covariates, under dominant and recessive models. We found a significant independent association of the 825T allele with VO2peak under the dominant model (β-coef.=−0.101, P=0.0442). We also observed that HRV marginally influenced VO2peak. This finding suggests that GNB3 C825T polymorphism is associated with VO2peak which is influenced by autonomic modulation of heart rate in African Americans.

Key words

GNB3 - cardiorespiratory fitness - heart rate variability - African-Americans - autonomic modulation

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Correspondence

Dr. M. U. FaruqueMD, PhD 

National Human Genome Center

Howard University

2041 Georgia Avenue

N.W.

Washington, D.C. 20060

United States

Phone: +202/806/41 80

Fax: +202/986/39 72

Email: mfaruque@howard.edu

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