Differential Effects of Propylthiouracil, Methimazole and Thyroidectomy on Liver Ferritin

U. R. Deshpande; G. D. Nadkarni

doi:10.1055/s-0029-1210284

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Exp Clin Endocrinol Diabetes 1983; 82(5): 242-245
DOI: 10.1055/s-0029-1210284

Short Communication

Differential Effects of Propylthiouracil, Methimazole and Thyroidectomy on Liver Ferritin

U. R. Deshpande, G. D. Nadkarni

Radiation Medicine Centre (Head: Dr. R. D. Ganatra) Parel, Bombay/India

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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

Different groups of rats were made hypothyroid by thyroidectomy (Tx) or treatment with propylthiouracil (PTU) or methimazole (MMI), Some of the hypothyroid rats from each group were simultaneously treated with thyroxine (T₄). Liver ferritin concentration and ¹⁴C-glycine incorporation into liver ferritin in these rats were studied. Only in MMI-treated rats the ferritin concentration was elevated, which was reduced by simultaneous T₄ treatment. PTU treatment resulted in 36–42% reduction in ferritin synthesis, which was not responsive to T₄. Thyroidectomy induced 23% enhancement in ferritin synthesis, which was normal in T₄-treated T_x rats. The possible causes for these differential effects in hypothyroid rats have been discussed.

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