Summary
Estrogen deficiency might increase responsiveness of bone to circulating endogenous
parathormone. To explore a possible relationship between parathormone action on bone
and estrogens we studied the activity of the bone isoenzyme of serum alkaline phosphatase
and the urinary excretion of hydroxyproline in 16 premenopausal and 24 postmenopausal
women with primary hyperparathyroidism with hyperparathyroid osteodystrophy. The postmenopausal
women with primary hyperparathyroidism had the B-ALP 4.30 ± 0.54 μkat/l, the urinary
hydroxyproline excretion 205.2 ± 22.2 mmol/mol creatinine and urinary calcium excretion
8.9 ± 0-5 mmol/24 hours, significantly increased in comparison with the group of women
with menstrual cycle and primary hyperparathyroidism who had B-ALP 2.12 ± 0.43 μkat/1,
the urinary hydroxyproline excretion 119.0 ± 14.9 mmol/mol creatinine and urinary
calcium excretion 7.7 ± 0.4 mmol/24 hours. Evidence supporting that estrogen deficiency
might increase responsiveness of bone to circulating endogenous parathormone was provided
by the demonstration that postmenopausal women with primary hyperparathyroidism had
increased bone turnover assessed by urinary hydroxyproline excretion and bone isoenzyme
of alkaline phosphatase in comparison with the group of premenopausal women with primary
hyperparathyroidism.
Key words
Hyperparathyroidism - alkaline phosphatase - pre- and postmenopausal women