Does Secretin Control Insulin Secretion?

A. V. Greco; R. Manna; G. Ghirlanda; L. Altomonte; A. Bertoli

doi:10.1055/s-0029-1210369

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Exp Clin Endocrinol Diabetes 1984; 84(4): 81-86
DOI: 10.1055/s-0029-1210369

Original

Does Secretin Control Insulin Secretion?

A. V. Greco, R. Manna, G. Ghirlanda, L. Altomonte, A. Bertoli

Istituto di Patologia Medica, Catholic University, Rome/Italy

Further Information

Publication History

1983

Publication Date:
17 July 2009 (online)

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Summary

The effect of secretin on insulin release has been studied in normal subjects after prestimulation with arginine. In order to make a comparison a pulse of glucose with arginine prestimulation was given.

A pulse of 1 U/kg b.w. of secretin provokes a secretion of insulin that is weak and brief compared to that provoked by glucose; thus secretin fails to potentiate arginine-induced insulin secretion.

Such a result does not support the hypothesis of secretin as the central hormone in the enteroinsular axis.

Key words

Secretin - insulin release - arginine - glucose