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Exp Clin Endocrinol Diabetes 1985; 85(2): 191-198
DOI: 10.1055/s-0029-1210435
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Prednison Therapy on Serum Levels of Thyroxine (T4), Triiodothyronine (T3), Reverse Triiodothyronine (rT3), T3-Binding Capacity, Basal TSH Level and TSH Response to Thyreoliberin (TRH) in Children

E. Słuszkiewicz
  • Second Clinic (Head: Prof. S. Nowak, M. D.), Institute of Pediatrics (Head: Prof. B. Dębiec, M. D.), Medical Academy of Łódź/ Poland
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

Effects of Prednison therapy on serum levels of T4, T3, rT3, TBC, basal TSH and TSH response to TRH in 10 children (7 with nephrotic syndrome, 3 with trombocytopenia) were studied.×

It has been found out that corticotherapy (Prednison 1 — 2 mg/kg/24 h; 2—4 weeks) causes a significant decrease of total T3 concentration together with a considerable rise of reverse T3 and lower T3-binding capacity. Basal TSH level was increased abouttwice; TSH response to TRH between both groups (without and with Prednison therapy) didnot differ significantly. The observations suggest the presence of hypothyroidism during chronic corticotherapy in children.

Key words

Prednison therapy - T4, T3, rT3 - TSH levels - TSH response - TRH

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