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Exp Clin Endocrinol Diabetes 1988; 92(4): 85-90
DOI: 10.1055/s-0029-1210785
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

EEG Changes in Untreated Hyperthyroidism and under the Conditions of Thyreostatic Treatment

H. J. Leubuscher1 , F. Herrmann, K. Hambsch, D. Langpeter, P. Mueller2 , D. Sorger3
  • 1Institute of Physiology (Director: Prof. Dr. sc. med. P. Schwartze), Karl-Marx-University, College of Medicine, Leipzig/GDR
  • 2Policlinical Department (Head: Prof. Dr. sc. med. K. Hambsch) of the Medical-Policlinical Institute (Director: OMR Prof. Dr. sc. med. B. Rogos) Karl-Marx-University, College of Medicine, Leipzig/GDR
  • 3Clinic of Radiology, (Director: Prof. Dr. sc. med. G. Schneider), Karl-Marx-University, College of Medicine, Leipzig/GDR
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Publikationsverlauf

1988

Publikationsdatum:
16. Juli 2009 (online)

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Summary

20 patients with hyperthyroidism were observed with repeated EEG measurements before and during treatment (ObsidanR; MethimazolR). 17 patients, before starting antithyroid therapy, had slight to moderate EEG abnormalities. A prevalence for moderate disturbances occurred for patients with a higher degree of hyperthyroidism. The dominant EEG frequency was higher than in euthyroid controls, but no exact correlation to T3-values could be observed. 16 patients showed abnormal reactivity to photic stimulation. One-week therapy by propranolol produced only a slight synchronizing effect in EEG's, where T3-values decreased. After 4 weeks selective therapy by MethimazolR all patients were euthyroid, but some EEG abnormalities persisted in 12 patients in a lower degree. The dominant EEG frequency decreased to control-group ranges and abnormal photic reac- tivity was reduced. After 6 months some EEG disturbances re-increased tendiatively, in 3 relapses excessively. These observations confirm the prognostic value of EEG measurements for the recogni- tion of occurrence and persistence of cerebral disturbances in severe metabolic dysfunctions.

Key words

EEG - Hyperthyroidism - Treatment effects