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Exp Clin Endocrinol Diabetes 1988; 92(4): 123-125
DOI: 10.1055/s-0029-1210792
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Remission of the Newly Diagnosed Type 1 Diabetes by Radiation of the Pancreas

A. Dempe1 , W. Baaske2 , R. v. Baehr3 , St. Küttner1 , G. Neubert1 , K. Neumeister2
  • 1First Clinic of Internal Medicine (Head: OMR Prof. Dr. sc. med. Dempe) County Hospital Friedrich Wolf, Karl-Marx-Stadt/DDR
  • 2Clinic of Radiology (Head: MR Prof. Dr. sc. med. Neumeister) County Hospital Friedrich Wolf, Karl-Marx-Stadt/DDR
  • 3Institute of Clinical Immunology (Head: Prof. Dr. sc. med. R. v. Baehr) Humboldt University Berlin/DDR
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1988

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The process of autoaggression of the IDDM causes an “insulitis” leading to the destruction of the β-cells. By photons (9 MV) in a total dose of 10 Gy, divided into 5 single doses at an interval of 2 days in each case we could get a total remission in 3 out of 4 diabetics, a partly remission in the fourth patient. The therapeutic effect lasts till now (1–6 months) without any further treatment. The combination of a radiation of 5 X1 Gy with 1 mg methylprednisolon/kg body weight at the beginning of the treatment leads to a partly remission in 5 out of 7 patients lasting 3–7 months hitherto. Beside the antiinflammatory effect of the radiation on the “insulitis” an effect on the activated lymphocytes can be supposed. Side effects were not observed. They need not to be expected in a local therapy in a relatively small field size with a low radiation dose. Further research is necessary to confirm the results.

Key words

Type 1 diabetes - Insulitis - Radiation - Remission