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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 157-162
DOI: 10.1055/s-0029-1210892
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Paradoxical Response of Plasma ß-Endorphin to Combined Administration of TRH and GnRH in Adrenal Disorders *)

G. Knappe, Helga Gerl, R.-I. Rückert, Yvonne Rückert, W. Rohde, F. Stahl
  • Clinic of Internal Medicine (Director: Prof. Dr. H. Berndt) and Institute of Experimental Endocrinology (Director: Prof. Dr. Dr. h. c. G. Dörner), Humboldt-University (Charité), Berlin/GDR
*) To Prof. Dr. Dr. G. Dörner on occasion of his 60th birthday.
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Publikationsverlauf

1988

Publikationsdatum:
16. Juli 2009 (online)

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Summary

The combined intravenous injection of TRH and GnRH elicited paradoxical responses of plasma β-endorphin in active and successfully treated pituitary dependent Cushing's disease as well as in ectopic ACTH syndrome and in congenital adrenal hyperplasia. No response was observed in Cushing's syndrome due to adrenal tumours. It is concluded that an abnormal response to inappropriate releasing hormones cannot verify the existence of a pituitary corticotrophic microadenoma.

Key words

β-Endorphin - Cushing's syndrome - Adrenal hyperplasia - TRH - GnRH