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Exp Clin Endocrinol Diabetes 1991; 98(6): 213-221
DOI: 10.1055/s-0029-1211120
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Inhibition of Prostaglandin Synthesis and the Release of Vasopressin and Oxytocin from the Rat Neurohypophysis: In Vitro Studies1)

Ewa Bojanowska, J. W. Guzek
  • Department of Pathophysiology (Head: Prof. Dr. J. W. Guzek), University School of Medicine, Łódź/Poland
1) Conducted under contract No. CPBP 06.03 with the Polish Academy of Sciences.
Further Information

Publication History

1990

Publication Date:
16 July 2009 (online)

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Summary

The basal and K+-evoked release of vasopressin (VP) and oxytocin (OT) from the neurointermediate lobes in vitro was determined under conditions of indomethacin-induced inhibition of prostaglandin (PG) synthesis. — The in vivo treatment with indomethacin (IM), administered to donor animals, did not modify the release of VP during resting conditions as well as during the potassium stimulation; on the contrary, both base-line and K+-evoked release of OT was significantly inhibited under such conditions. Incubation of neurointermediate lobes in a solution containing indomethacin resulted in an inhibition of VP and OT release both during resting conditions and during depolarization due to excess potassium.

Key words

Indomethacin - Prostaglandins - Vasopressin - Oxytocin