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Exp Clin Endocrinol Diabetes 1993; 101(4): 262-264
DOI: 10.1055/s-0029-1211242
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Stimulatory Action of Porcine Follicular Fluid on Granulose cell Secretion of Cyclic GMP

J. Kolena, A. Danišová, L. Matulová, S. Scsuková
  • Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava/Slovakia
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Publikationsdatum:
15. Juli 2009 (online)

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Summary

Effects of FSH, LH and follicular fluid isolated from preovulatory follicles on secretion of progesterone, cAMP a cGMP by cultured immature porcine granulosa cells were investigated. Exposure of granulosa cells to gonadotropins and follicular fluid resulted in increase of progesterone and cGMP formation. Follicular fluid had an inhibitory effect on cAMP synthesis. The findings suggest a possible intermediary role of cGMP for the stimulatory action of follicular fluid in the process of luteinization of granulosa cells.

Key words

Follicular fluid - cAMP - cGMP - Progesterone - Granulosa cells