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Exp Clin Endocrinol Diabetes 1993; 101(5): 315-318
DOI: 10.1055/s-0029-1211251
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Increased Plasma Endothelin-1 Concentrations in E. coli Septic Peritonitis Rats with Diabetes Mellitus

K. Tsukada, H. Katoh, M. Shiojima, T. Suzuki, S. Takenoshita, Y. Nagamachi
  • First Department of Surgery, Gunma University, School of Medicine, Maebashi, 371, Japan
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

To study the diabetic mellitus (DM) patient's reaction to sepsis, we investigated the survival rate, the bacteremia, plasma endotoxin and plasma endothelin-1 levels in E.coli septic peritonitis rats with or without streptozotocin-induced DM. No significant difference could be detected between the DM and nondiabetic rats in the survival rate, the bacteremia level or the plasma endotoxin level. The DM rat manifested a significant increase compared to the nondiabetic rat in the plasma endothelin-1 level four hours after the outbreak of peritonitis. Endothelin-1 may thus play some role in the E. coli septic peritonitis rat with DM.

Key words

endothelin-1 - diabetes mellitus - E.coli septic peritonitis

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