PDF herunterladen
Exp Clin Endocrinol Diabetes 1997; 105(6): 363-365
DOI: 10.1055/s-0029-1211780
Case Report

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Ectopic ACTH-Syndrome due to ovarian carcinoma

M. Orbetzova, M. Andreeva, S. Zacharieva, R. Ivanova* , G. Dashev*
  • Clinic of Hypothalamo-Hypophyseal and Adrenal Diseases
  • * Pathomorphological Department, Clinical Centre of Endocrinology and Gerontology, Sofia, Bulgaria
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
14. Juli 2009 (online)

Auch verfügbar auf
 als PDF herunterladen  Lizenzen und Reprints

Summary

The case of a 60-year-old female with severe and rapidly progressing Cushing's syndrome with fatal consequences is described. Both the clinical and the biochemical findings were consistent with ectopic ACTH production. A computed tomographic (CT) scan revealed intact pituitary and enlarged adrenal glands. Liver metastases were seen but the primary neoplasm was not found. Treatment with aminoglutethimide and other therapeutic measures were unsuccessful. A carcinoma of the right ovary was discovered on autopsy. The tumour cells showed immunoreactivity for neuron-specific enolase (NSE), ACTH and β-endorphin with differing degree of intensity.

Key words

Ovarian carcinoma - ectopic ACTH-syndrome