Abstract
Spirocycles, including spirocyclic ethers, occur frequently in
natural products and pharmaceutically active substances. Accordingly,
synthetic methodologies utilized for the preparation of such compounds
are of broad interest. The present review focuses on the general
synthetic approaches that have been utilized for the construction
of spirocyclic ethers during the past two decades.
1 Introduction
2 Scope
3 Rearrangement Methods
4 Alkylation Methods
5 Ring Closure of Geminally Disubstituted Cyclic Compounds
6 Ring-Closing Metathesis
7 Other Transition-Metal-Based Processes
8 Radical Cyclizations
9 Cycloaddition Methods
10 Conclusion
Key words
spiro compounds - ethers - ring closure - stereoselective synthesis - natural products
