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Synfacts 2010(1): 0066-0066
DOI: 10.1055/s-0029-1218480
DOI: 10.1055/s-0029-1218480
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Reduction of Quinoxalines
N. Mršić, T. Jerphagnon, A. J. Minnaard*, B. L. Feringa*, J. G. de Vries*
University of Groningen and DSM Pharmaceutical Products, Geleen, The Netherlands
Further Information
Publication History
Publication Date:
21 December 2009 (online)
Significance
The authors describe an iridium-catalyzed hydrogenation of quinoxalines giving products in high yields and enantioselectivities. The reduction of substituted heteroaromatic compounds to give chiral building blocks is a well-established strategy (see Review below). This report outlines conditions giving superior selectivities for these particular heterocycles compared to previous reports.
Review: Y.-G. Zhou Acc. Chem. Res. 2007, 40, 1357-1366.