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Dtsch Med Wochenschr 2009; 134(15): 740-746
DOI: 10.1055/s-0029-1220224
DOI: 10.1055/s-0029-1220224
Übersicht | Review article
Kardiologie, Labormedizin© Georg Thieme Verlag KG Stuttgart · New York
Biomarker bei Herzinsuffizienz: klinischer Stellenwert belegt?
Biomarkers in heart failure: are they clinically useful?Further Information
Publication History
eingereicht: 16.12.2008
akzeptiert: 12.2.2009
Publication Date:
01 April 2009 (online)

Schlüsselwörter
Biomarker - Herzinsuffizienz - natriuretische Peptide - BNP - NT-proBNP - Troponin - GDF-15
Keywords
biomarkers - heart failure - natriuretic peptides - BNP - NT-proBNP - troponin - GDF-15
Literatur
- 1
Anand I S.
Anemia and chronic heart failure implications
and treatment options.
J Am Coll Cardiol.
2008;
52
501-511
MissingFormLabel
- 2
Anand I S, Kuskowski M A, Rector T S. et al .
Anemia and change in hemoglobin
over time related to mortality and morbidity in patients with chronic
heart failure: results from Val-HeFT.
Circulation.
2005;
112
1121-1127
MissingFormLabel
- 3
Anker S D, Doehner W, Rauchhaus M. et al .
Uric acid and survival in chronic heart
failure: validation and application in metabolic, functional, and
hemodynamic staging.
Circulation.
2003;
107
1991-1997
MissingFormLabel
- 4
Babuin L, Jaffe A S.
Troponin: the biomarker
of choice for the detection of cardiac injury.
Can Med
Assoc J.
2005;
173
1191-1202
MissingFormLabel
- 5
Braunwald E.
Biomarkers in heart failure.
New Engl J Med.
2008;
358
2148-2159
MissingFormLabel
- 6
Bursi F, Weston S A, Redfield M M. et al .
Systolic and diastolic heart
failure in the community.
JAMA.
2006;
296
2209-2216
MissingFormLabel
- 7
Pfisterer M, Buser P, Rickli H. et al .
BNP-guided vs symptom-guided heart failure
therapy: the trial of Intensified vs standard medical therapy in
elderly patients with congestive heart failure (TIME-CHF) randomized
trial.
JAMA.
2009;
301
383-392
MissingFormLabel
- 8
Cowie M R, Struthers A D, Wood D A. et al .
Value of natriuretic peptides in
assessment of patients with possible new heart failure in primary care.
Lancet.
1997;
350
1349-1353
MissingFormLabel
- 9
Daniels L B, Maisel A S.
Natriuretic
peptides.
J Am Coll Cardiol.
2007;
50
2357-2368
MissingFormLabel
- 10
Dickstein K, Cohen-Solal A, Filippatos G. et al .
ESC Guidelines for the diagnosis and treatment
of acute and chronic heart failure 2008.
Eur Heart J.
2008;
29
2388-2442
MissingFormLabel
- 11
Fonarow G C, Adams Jr K F, Abraham W T, Yancy C W, Boscardin W J.
Risk stratification
for in-hospital mortality in acutely decompensated heart failure:
classification and regression tree analysis.
JAMA.
2005;
293
572-580
MissingFormLabel
- 12
Forman D E, Butler J, Wang Y. et
al .
Incidence, predictors at admission, and impact
of worsening renal function among patients hospitalized with heart
failure.
J Am Coll Cardiol.
2004;
43
61-67
MissingFormLabel
- 13
Gerszten R E, Wang T J.
The search for
new cardiovascular biomarkers.
Nature.
2008;
451
949-952
MissingFormLabel
- 14
Ginsburg G S, McCarthy J J.
Personalized
medicine: revolutionizing drug discovery and patient care.
Trends
Biotechnol.
2001;
19
491-496
MissingFormLabel
- 15
Goldsmith S R.
Current treatments and novel pharmacologic treatments for hyponatremia
in congestive heart failure.
Am J Cardiol.
2005;
95
14B-23B
MissingFormLabel
- 16
Gustafsson F, Steensgaard-Hansen F, Badskjaer J, Poulsen A H, Corell P, Hildebrandt P.
Diagnostic
and prognostic performance of N-terminal ProBNP in primary care
patients with suspected heart failure.
J Card Fail.
2005;
11
S15-20
MissingFormLabel
- 17
Hare J M, Mangal B, Brown J. et al .
Impact of oxypurinol in patients with symptomatic
heart failure. Results of the OPT-CHF study.
J Am Coll
Cardiol.
2008;
51
2301-2309
MissingFormLabel
- 18
Heywood J T, Fonarow G C, Costanzo M R, Mathur V S, Wigneswaran J R, Wynne J.
High
prevalence of renal dysfunction and its impact on outcome in 118,465
patients hospitalized with acute decompensated heart failure: a
report from the ADHERE database.
J Card Fail.
2007;
13
422-430
MissingFormLabel
- 19
Hillege H L, Nitsch D, Pfeffer M A. et al .
Renal function as a predictor of outcome
in a broad spectrum of patients with heart failure.
Circulation.
2006;
113
671-678
MissingFormLabel
- 20
Hoppe U C, Bohm M, Dietz R. et
al .
Guidelines for therapy of chronic heart failure.
Z Kardiol.
2005;
94
488-509
MissingFormLabel
- 21
Horwich T B, Fonarow G C, Hamilton M A, MacLellan W R, Borenstein J.
Anemia is associated with worse symptoms,
greater impairment in functional capacity and a significant increase
in mortality in patients with advanced heart failure.
J
Am Coll Cardiol.
2002;
39
1780-1786
MissingFormLabel
- 22
Januzzi Jr J L, Camargo C A, Anwaruddin S. et al .
The N-terminal Pro-BNP investigation
of dyspnea in the emergency department (PRIDE) study.
Am
J Cardiol.
2005;
95
948-954
MissingFormLabel
- 23
Jessup M, Brozena S.
Heart failure.
New
Engl J Med.
2003;
348
2007-2018
MissingFormLabel
- 24
Jourdain P, Jondeau G, Funck F. et al .
Plasma brain natriuretic peptide-guided
therapy to improve outcome in heart failure: the STARS-BNP Multicenter
Study.
J Am Coll Cardiol.
2007;
49
1733-1739
MissingFormLabel
- 25
Kempf T, Eden M, Strelau J. et
al .
The transforming growth factor-beta superfamily
member growth-differentiation factor-15 protects the heart from
ischemia/reperfusion injury.
Circ Res.
2006;
98
351-360
MissingFormLabel
- 26
Kempf T, von Haehling S, Peter T. et al .
Prognostic utility of growth differentiation
factor-15 in patients with chronic heart failure.
J Am Coll
Cardiol.
2007;
50
1054-1060
MissingFormLabel
- 27
Klein L, O’Connor C M, Leimberger J D. et al .
Lower serum sodium
is associated with increased short-term mortality in hospitalized
patients with worsening heart failure: results from the Outcomes
of a Prospective Trial of Intravenous Milrinone for Exacerbations
of Chronic Heart Failure (OPTIME-CHF) study.
Circulation.
2005;
111
2454-2460
MissingFormLabel
- 28
Konstam M A, Gheorghiade M, Burnett Jr J C. et al .
Effects of oral
tolvaptan in patients hospitalized for worsening heart failure:
the EVEREST Outcome Trial.
JAMA.
2007;
297
1319-1331
MissingFormLabel
- 29
Lassus J, Harjola V P, Sund R. et al .
Prognostic value of cystatin C in acute
heart failure in relation to other markers of renal function and NT-proBNP.
Eur Heart J.
2007;
28
1841-1847
MissingFormLabel
- 30
Latini R, Masson S, Anand I S. et al .
Prognostic value of very low plasma concentrations
of troponin T in patients with stable chronic heart failure.
Circulation.
2007;
116
1242-1249
MissingFormLabel
- 31
Latini R, Masson S, Wong M. et
al .
Incremental prognostic value of changes in B-type
natriuretic peptide in heart failure.
Am J Med.
2006;
119
70 e23-e30
MissingFormLabel
- 32
Lee W H, Packer M.
Prognostic importance
of serum sodium concentration and its modification by converting-enzyme
inhibition in patients with severe chronic heart failure.
Circulation.
1986;
73
257-267
MissingFormLabel
- 33
Levy W C, Mozaffarian D, Linker D T. et al .
The Seattle Heart Failure Model:
prediction of survival in heart failure.
Circulation.
2006;
113
1424-1433
MissingFormLabel
- 34
Maisel A, Hollander J E, Guss D. et al .
Primary results of the Rapid Emergency
Department Heart Failure Outpatient Trial (REDHOT). A multicenter
study of B-type natriuretic peptide levels, emergency department
decision making, and outcomes in patients presenting with shortness
of breath.
J Am Coll Cardiol.
2004;
44
1328-1333
MissingFormLabel
- 35
Maisel A, Mueller C, Adams Jr K. et al .
State of the art: using natriuretic peptide
levels in clinical practice.
Eur J Heart Fail.
2008;
10
824-839
MissingFormLabel
- 36
Maisel A S, Krishnaswamy P, Nowak R M. et al .
Rapid measurement of B-type
natriuretic peptide in the emergency diagnosis of heart failure.
New Engl J Med.
2002;
347
161-167
MissingFormLabel
- 37
Mann D L, Bristow M R.
Mechanisms
and models in heart failure: the biomechanical model and beyond.
Circulation.
2005;
111
2837-2849
MissingFormLabel
- 38
Masson S, Latini R, Anand I S. et al .
Direct comparison of B-type natriuretic
peptide (BNP) and amino-terminal proBNP in a large population of
patients with chronic and symptomatic heart failure: the Valsartan
Heart Failure (Val-HeFT) data.
Clin Chem.
2006;
52
1528-1538
MissingFormLabel
- 39
Moe G W, Howlett J, Januzzi J L, Zowall H.
N-terminal pro-B-type
natriuretic peptide testing improves the management of patients
with suspected acute heart failure: primary results of the Canadian
prospective randomized multicenter IMPROVE-CHF study.
Circulation.
2007;
115
3103-3110
MissingFormLabel
- 40
Morrow D A, de Lemos J A.
Benchmarks
for the assessment of novel cardiovascular biomarkers.
Circulation.
2007;
115
949-952
MissingFormLabel
- 41
Mueller C, Scholer A, Laule-Kilian K. et al .
Use of B-type natriuretic peptide in the
evaluation and management of acute dyspnea.
New Engl J
Med.
2004;
350
647-654
MissingFormLabel
- 42
Nickel N, Kempf T, Tapken H. et al .
Growth differentiation factor-15 in idiopathic
pulmonary arterial hypertension.
Am J Resp Crit Care Med.
2008;
178
534-541
MissingFormLabel
- 43
Pascual-Figal D A, Hurtado-Martinez J A, Redondo B, Antolinos M J, Ruiperez J A, Valdes M.
Hyperuricaemia and long-term outcome after hospital discharge
in acute heart failure patients.
Eur J Heart Fail.
2007;
9
518-524
MissingFormLabel
- 44
Paulus W J, Tschöpe C, Sanderson J E. et al .
How to diagnose diastolic heart
failure: a consensus statement on the diagnosis of heart failure with
normal left ventricular ejection fraction by the Heart Failure and
Echocardiography Associations of the European Society of Cardiology.
Eur Heart J.
2007;
28
2539-2550
MissingFormLabel
- 45
Peacock W FT, De Marco T, Fonarow G C. et al .
Cardiac troponin and outcome in acute heart
failure.
New Engl J Med.
2008;
358
2117-2126
MissingFormLabel
- 46
Redfield M M, Rodeheffer R J, Jacobsen S J, Mahoney D W, Bailey K R, Burnett C Jr J.
Plasma brain natriuretic peptide to detect
preclinical ventricular systolic or diastolic dysfunction: a community-based
study.
Circulation.
2004;
109
3176-3181
MissingFormLabel
- 47
Rehman S U, Mueller T, Januzzi L
Jr J.
Characteristics of the novel interleukin family
biomarker ST2 in patients with acute heart failure.
J Am
Coll Cardiol.
2008;
52
1458-1465
MissingFormLabel
- 48
Schiffrin E L, Lipman M L, Mann J F.
Chronic kidney disease: effects on the cardiovascular
system.
Circulation.
2007;
116
85-97
MissingFormLabel
- 49
Schlittenhardt D, Schober A, Strelau J. et al .
Involvement of growth differentiation factor-15/macrophage
inhibitory cytokine-1 (GDF-15/MIC-1) in oxLDL-induced apoptosis
of human macrophages in vitro and in arteriosclerotic lesions.
Cell Tissue Res.
2004;
318
325-333
MissingFormLabel
- 50
Tang W H, Van Lente F, Shrestha K. et al .
Impact of myocardial function on cystatin
C measurements in chronic systolic heart failure.
J Card Fail.
2008;
14
394-399
MissingFormLabel
- 51
Vasan R S, Benjamin E J, Larson M G. et al .
Plasma natriuretic peptides for
community screening for left ventricular hypertrophy and systolic
dysfunction: the Framingham heart study.
JAMA.
2002;
288
1252-1259
MissingFormLabel
- 52
Weinberg E O, Shimpo M, De Keulenaer G W. et al .
Expression and regulation
of ST2, an interleukin-1 receptor family member, in cardiomyocytes
and myocardial infarction.
Circulation.
2002;
106
2961-2966
MissingFormLabel
- 53
Weinberg E O, Shimpo M, Hurwitz S, Tominaga S, Rouleau J L, Lee R T.
Identification
of serum soluble ST2 receptor as a novel heart failure biomarker.
Circulation.
2003;
107
721-726
MissingFormLabel
- 54
Wollert K C, Kempf T, Lagerqvist B. et al .
Growth differentiation factor 15 for risk
stratification and selection of an invasive treatment strategy in
non ST-elevation acute coronary syndrome.
Circulation.
2007;
116
1540-1548
MissingFormLabel
- 55
Wollert K C, Kempf T, Peter T. et
al .
Prognostic value of growth-differentiation factor-15
in patients with non-ST-elevation acute coronary syndrome.
Circulation.
2007;
115
962-971
MissingFormLabel
- 56
Wright S P, Doughty R N, Pearl A. et al .
Plasma amino-terminal pro-brain natriuretic
peptide and accuracy of heart-failure diagnosis in primary care:
a randomized, controlled trial.
J Am Coll Cardiol.
2003;
42
1793-1800
MissingFormLabel
- 57
Xu J, Kimball T R, Lorenz J N. et al .
GDF15/MIC-1 functions
as a protective and antihypertrophic factor released from the myocardium
in association with SMAD protein activation.
Circ Res.
2006;
98
342-350
MissingFormLabel
Prof. Dr. med. Kai C. Wollert
Klinik für Kardiologie und Angiologie, Medizinische
Hochschule Hannover
Carl-Neuberg-Str. 1
30625
Hannover
Phone: 0511/532-4055
Fax: 0511/532-5307
Email: wollert.kai@mh-hannover.de